Wright remained active in the '80s. Her 1981 self-titled album featured "What Are You Going To Do With It," a minor hit composed by Stevie Wonder. The year before, she (along with Michael Jackson and Eddie Levert of the O’Jays) background vocals on Wonder’s platinum album Hotter Than July. In 1982, Betty’s guest appearance on Richard "Dimples" Fields' Dimples hit "She's Got Papers on Me" firmly stole the show. In 1983, she released the album Wright Back at You, which featured compositions and production by Marlon Jackson of the Jacksons.
In 1985, after yet major record company relationship ended in frustration, Betty made the game-changing decision to form her own independent label, Ms B Records. The label’s debut album, Sevens, featured the hit single “Pain”. Two years later, Wright made history as the first female artist to score a gold album on her own label, when her 1987 album, Mother Wit achieved that certification within just 12 months of its release. The album was notable for the hit sequels “After the Pain” and "No Pain, No Gain," which returned her to the R&B Top 20 charts for the first time in a decade.
Betty Wright is one of the few entertainers of any genre that has been relevant to the music business for every decade of the last 60 years. She began the nineties with her first Top Twenty Adult Contemporary placement when Grayson Hugh tapped her to duet with him on a remake of “How Bout Us” for the True Love film soundtrack, and the single peaked at No.15. A couple of years later, her successful litigation against pop group Color Me Bad for their illegal sampling of “Tonight Is the Night” set legal precedent for similar cases. Legal samples from the song have become a staple in the world of hip hop appearing on records by Tupac, Li’l Wayne, and others. As the new millennium took shape Betty Wright was introduced to the MTV generation as the go-to vocal coach for Diddy’s first two incarnations of Making the Band.
Wright would gain a new wave of younger followers and fans through her collaborations with next-gen artists and producers in the 2000s. Her production work on Joss Stone's first two albums earned her high accolades: 2003's The Soul Sessions was shortlisted for the Mercury Prize in the U.K., according to Billboard, while 2004's Mind Body & Soul garnered Wright a GRAMMY nomination for Best Pop Vocal Album (as a producer along with Steve Greenberg and Mike Mangini). Her collaborations with Angie Stone (“Baby”) and Lil Wayne earned her back to back GRAMMY nods in 2007.
In 2011, she released Betty Wright: The Movie, a collaborative album with The Roots, which featured collaborations with Snoop Dogg, Lil Wayne and Joss Stone, among others. "Surrender," a featured track off the album, garnered Wright her sixth and final artist GRAMMY nomination, for Best Traditional R&B Performance, at the 54th GRAMMY Awards, held in 2012. Wright spent much of the next few years mentoring a new generation of artists, producers and writers in a workshop program she dubbed the M.O.S.T. (an acronym for Mountains of Songs Together). She also teamed up once again with Greenberg and Mangini to produce The O’Jays first studio album in 15 years, The Last Word. In 2016, she joined hip hop superstar DJ Khaled alongside rappers Kendrick Lamar and Big Sean on the title track of his hit album Holy Key. Their performance of the track during the BET Hip Hop awards was a showstopper, and Betty’s signature high note went viral on social media platforms.